Sedaris was born in Endicott, New York, the fourth of six children in a Greek Orthodox family. Her parents were Sharon Elizabeth (née Leonard), a homemaker, and Louis Harry "Lou" Sedaris, an IBM engineer. Her father was … See more

In the late 1980s, she was hired to perform with Second City's touring company. It was there she met Paul Dinello and Stephen Colbert with whom she often collaborated later in her career. She and Dinello did not get along w… See more